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Table 1 Comparison of methods of emergency contraception

From: State of emergency contraception in the U.S., 2018

  Copper IUD UPA LNG
Efficacya, b, c, d 1
Most effective overall
2
Not as effective as copper IUD; most effective ECP
2
Less effective than copper IUD or UPA
Timing of useb, c, d, e, f Typically 5 days after UPI (120 h), but may be effective at any point in the cycle 5 days after UPI (120 h) 3 days after UPI (72 h), although may have efficacy up to 120 h
Available OTCc, g No No Yes
Timing of long-term birth control after useb, c Leave in for continued use for up to 12 years Wait 5 days Immediately (quick-start)
Dosageb, g N/A, insertion by medical provider 30 mg, one dose 1.5 mg, one dose
BMIg, h 1
No decrease in efficacy by BMI
2
Decrease in efficacy for BMI ≥ 30
2
Decrease in efficacy for BMI ≥ 25
Breastfeedinge 1 1 1
Hx of severe cardiovascular diseasee 1 2 2
Migrainee 1 1 1
Severe liver diseasee 1 2 2
CYP3A4 inducerse 1 2 2
  1. IUD intrauterine device, UPA ulipristal acetate, LNG levonorgestrel, ECP emergency contraception pill, UPI unprotected intercourse, OTC over-the-counter, N/A not applicable, mg milligrams, BMI body mass index, Hx history. CDC MEC Categories for classifying emergency contraception: “1 = A condition for which there is no restriction for the use of the contraceptive method; 2 = A condition for which the advantages of using the method generally outweigh the theoretical or proven risks” b
  2. aACOG Committee Opinion [68],
  3. bCurtis, Jatlaoui, Tepper, et al. [13],
  4. cTrussel, Raymond, Cleland [29],
  5. dFSRH, 2017 [14]
  6. eCurtis, Tepper, Jatlaoui, et al. [40],
  7. fEmergency contraception should be taken as soon as possible following UPI
  8. gACOG Practice Bulletin [30],
  9. hGlasier, Cameron, Blithe, et al. [35],