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Table 1 Comparison of methods of emergency contraception

From: State of emergency contraception in the U.S., 2018

 

Copper IUD

UPA

LNG

Efficacya, b, c, d

1

Most effective overall

2

Not as effective as copper IUD; most effective ECP

2

Less effective than copper IUD or UPA

Timing of useb, c, d, e, f

Typically 5 days after UPI (120 h), but may be effective at any point in the cycle

5 days after UPI (120 h)

3 days after UPI (72 h), although may have efficacy up to 120 h

Available OTCc, g

No

No

Yes

Timing of long-term birth control after useb, c

Leave in for continued use for up to 12 years

Wait 5 days

Immediately (quick-start)

Dosageb, g

N/A, insertion by medical provider

30 mg, one dose

1.5 mg, one dose

BMIg, h

1

No decrease in efficacy by BMI

2

Decrease in efficacy for BMI ≥ 30

2

Decrease in efficacy for BMI ≥ 25

Breastfeedinge

1

1

1

Hx of severe cardiovascular diseasee

1

2

2

Migrainee

1

1

1

Severe liver diseasee

1

2

2

CYP3A4 inducerse

1

2

2

  1. IUD intrauterine device, UPA ulipristal acetate, LNG levonorgestrel, ECP emergency contraception pill, UPI unprotected intercourse, OTC over-the-counter, N/A not applicable, mg milligrams, BMI body mass index, Hx history. CDC MEC Categories for classifying emergency contraception: “1 = A condition for which there is no restriction for the use of the contraceptive method; 2 = A condition for which the advantages of using the method generally outweigh the theoretical or proven risks” b
  2. aACOG Committee Opinion [68],
  3. bCurtis, Jatlaoui, Tepper, et al. [13],
  4. cTrussel, Raymond, Cleland [29],
  5. dFSRH, 2017 [14]
  6. eCurtis, Tepper, Jatlaoui, et al. [40],
  7. fEmergency contraception should be taken as soon as possible following UPI
  8. gACOG Practice Bulletin [30],
  9. hGlasier, Cameron, Blithe, et al. [35],